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L-arginine is an amino acid that you can find naturally in foods like fish, meat and nuts. L-arginine is semi-essential (conditional), which means that your body can produce the amino acid, but you also need to include some sources of the amino acid in your diet.
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Depending on your reason for taking l-arginine and which type of amino acid you need, it takes a minimum of 24-hours for the l-arginine to absorb into your body. In some cases, to see the full effects of regular l-arginine treatment, it could take up to three months.
Always talk with your healthcare provider before starting any new supplements like l-arginine. L-arginine is safe for most adults, especially if you incorporate more protein-forward products into your diet like meat and nuts. If you have any serious reactions to the amino acid, contact your provider or visit the emergency room immediately.
Arginine may be insufficient in pregnancy [2]. Concentrations of asymmetric dimethyl arginine, a competitive inhibitor of nitric oxide synthase, are raised in women with pre-eclampsia [3]. As also endoglin which impairs the activation of nitric oxide synthase mediated by transforming growth factor β [4]. Supplemental l-arginine in the diet could provide a source of substrate for nitric oxide synthesis during pregnancy, which could promote vasodilatation. There are however limited studies in the use of l-arginine and other nitric oxide donators for preventing pre-eclampsia, as stated in the Cochrane review by Meher and Duley [5]. Existing literature suggests that l-arginine has direct effects on blood pressure in experimental animal models, normal humans, hypertensive patients, women with pre-eclampsia, and healthy pregnant women [6, 7]. In pre-eclampsia the role of arginine may be limited after the establishment of the condition, as is mentioned by Staff et al. [8] in a study where no effect of l-arginine was manifest when used in women with pre-eclampsia beyond 28 weeks of gestation. Germain et al. [9] disclosed some initial findings in women at high risk of pre-eclampsia who received l-arginine from week 10 of gestation. In a study in 2005 it was seen that in pre-eclamptic patients prolonged dietary treatment with low dose of l-arginine significantly decreased maternal blood pressure and increased bioavailability of endothelial nitric oxide [10].
L-arginine also stimulates the release of growth hormone, insulin, and other substances in the body. Increased strength through building muscle mass is not the only benefit of L-arginine for bodybuilding. By serving as a precursor for the vasodilator, nitric oxide, L-arginine promotes endurance and muscle conditioning. When nitric oxide is released, it widens the blood vessels by relaxing the muscles of their walls. This lowers blood pressure and increases blood flow to the muscles during workouts. The increased blood flow means that oxygen and nutrients are adequately supplied to your muscles and for longer amounts of time. This can help reduce muscle damage, promote healing and provide peak performance.
L-arginine is an amino acid that aids in the formation of proteins in the body. Athletes and others look for ways to increase their L-arginine consumption, such as taking supplements.
L-arginine is generally believed to be safe. Despite the fact that greater doses are frequently used in research and clinical settings, daily L-arginine dosing is recommended to keep around 9 grams per day to avoid any negative effects.
L-arginine from MaxN helps with endurance and muscle conditioning. It is converted into nitric oxide in the body, which expands blood arteries by relaxing the muscles that line their walls. This decreases blood pressure and boosts blood flow to the muscles during workouts.
Different medical interventional methods have been tried to treat oligohydramnios. This study was done to find out the effect of l-arginine on AFI, the mode of delivery, and the fetal outcome. l-arginine, a semi-essential amino acid and the sole endogenous precursor of nitric oxide (NO), is involved in the regulation of blood flow in vascular beds [1]. It is an important regulator of placental perfusion [2]. It causes vasodilatation and shows aggregative effect on platelets. This mechanism increases the volume and viscosity of blood in the fetomaternal circulation [3].
Patients were administered l-arginine 3 gm per sachet in oral form. Serial ultrasound monitoring at regular intervals was performed, and patients were followed up till delivery. Effect of l-arginine on oligohydramnios and intrauterine growth was analyzed.
Close monitoring was carried out for any hemodynamic alterations. Patient compliance was good, and no detrimental side effects were noted due to l-arginine intervention. The treatment was continued till the liquor improved significantly. Additional risk factors were managed as per usual standard protocols. Serial non-stress test (NST) and biophysical profile (BPP) were mandatory as a monitoring protocol for all patients. However, patients were considered for delivery if the liquor remained
l-arginine is a semi-essential amino acid acting as a substrate for synthesis of NO [7]. NO has a diverse role in obstetrics as it plays a vital role in labor, cervical ripening, preeclampsia, and intrauterine growth restriction. Nitric oxide (NO) is an important regulator of placental perfusion and plays an important role in placental vascular endothelial function. NO is synthesized from the physiologic precursor l-arginine by stereospecific enzyme NO synthase in what is called the l-arginine/NO pathway, and l-arginine is the only substrate for the NO [8]. NO diffuses into the underlying vascular smooth muscle cells and mediates vasodilatation and platelet stabilization by a cyclic GMP-dependant process [9].
l-arginine promotes intrauterine growth of the fetus by increasing bioavailability of endothelial nitric oxide (NO) production and improving the umbilical artery flow in pregnant women with pregnancy-induced hypertension and fetal growth restriction.
l-Arginine is also reported to improve growth hormone releasing hormone secretion and as a consequence increase in plasmatic growth hormone influencing somatic growth. It is also suggested that it may play a significant role in fetal growth, by stimulating insulin secretion, and as a precursor for both polyamine synthesis and NO production [10]. l-arginine treatment accelerates fetal weight gain and improves biophysical profile [11].
Gene expression and protein tissue content of arginase II (enzyme that degrades arginine to ornithine) were found to be higher in preeclamptic villi than in normotensive pregnancy [12]. Arginase II over-expression is seen in lower l-arginine concentration which causes increase in peroxynitrite (isoform of nitric oxide synthase). Peroxynitrite is a cytotoxic anion that inhibits mitochondrial electron transport, oxidizes proteins, initiates lipid peroxidation, and nitrates aromatic amino acid. Peroxynitrite by causing vascular damage contributes to the increased placental vascular resistance [13].
The combination of a deficiency of NO and increase in peroxynitrite is associated with placental dysfunction, increased thromboxanes and endothelin 1, and decrease in prostacyclins. Therefore, studies recommend the supplementation of l-arginine and antioxidants in pregnancy to maintain the levels of NO so as to facilitate the required vasodilatation and have a beneficial role in the fetal growth.
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L-arginine (el-AHR-jih-nene) is an organic substance called an amino acid. The body usually makes all the L-arginine it needs. You also get L-arginine through your diet in foods such as nuts, fish, red meat, soy, whole grains, beans and dairy products.
The body changes L-arginine to nitric oxide, a substance known to widen blood vessels. Some people take L-arginine supplements to relax and open arteries, which might help lower blood pressure. However, L-arginine supplements are rarely necessary and may only benefit people who have a true deficiency.
A review of several studies found that adults with high blood pressure who took daily L-arginine supplements lowered their bottom (diastolic) blood pressure number by about 2 to 3 millimeters of mercury (mm Hg).
When it comes to heart health, L-arginine may work better when combined with other vitamins, such as vitamins B6 and B12. However, larger, more-robust studies are needed to confirm these findings before experts can recommend everyday use of these supplements.
A healthy diet and regular exercise are among the best ways to keep your blood pressure healthy. If you're thinking about taking an herbal or dietary supplement, such as L-arginine, talk to your health care provider first. Some supplements can interact with blood pressure medications or make certain health conditions worse.
Arginine is a non-essential amino acid which assists the removal of ammonia from the body which is a waste product of protein metabolism. It is an essential precursor of nitric oxide. The amino acid arginine has several roles in the body, such as helping remove ammonia from the body which is a waste product of protein metabolism. Arginine is also an essential precursor of nitric oxide which helps maintain blood vessel tone.
The study above found 8% of people taking L-arginine experienced side effects compared to 2% of those taking placebo. When taken in combination with other natural supplements like yohimbe, subjects reported mild side effects, including insomnia, headache, and itching (Rhim, 2019).
Pycnogenol, an extract made from the bark of the French maritime pine tree, may also increase nitric oxide levels in the body. One small study reported that after one month of treatment with a combination of L-arginine and pycnogenol, only 5% of study participants experienced better erections. But after three months of treatment, nearly 93% of men could experience a normal erection (Stanislavov, 2003). 041b061a72